发明名称 |
METHODS OF CRYSTAL PRECIPITATION |
摘要 |
<p>Crystals of paroxetine hydrochloride 1/2-hydrate are allowed to separate out by adding water to a solution or suspension comprising paroxetine hydrochloride and a polar organic solvent which contains no water or at most 60% by weight of water to adjust the water content to at least 70% by weight when crystals of paroxetine hydrochloride 1/2-hydrate are allowed to separate out in a water-containing polar organic solvent. Crystals of paroxetine hydrochloride 1/2-hydrate being not colored in pink can be allowed to separate out in the presence of hydrogen chloride when crystals of paroxetine hydrochloride 1/2-hydrate are allowed to separate out in water or a water-containing polar organic solvent.</p> |
申请公布号 |
EP1555262(A1) |
申请公布日期 |
2005.07.20 |
申请号 |
EP20030751270 |
申请日期 |
2003.09.17 |
申请人 |
SUMITOMO CHEMICAL COMPANY, LIMITED |
发明人 |
YAMAZAKI, SHIGEYA;YOSHIKAWA, TAICHI |
分类号 |
C07D263/58;C07D405/12;(IPC1-7):C07D405/12 |
主分类号 |
C07D263/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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