| 发明名称 |
Methods and Means for Treatment of Osteoarthritis |
| 摘要 |
The invention relates to the field of medicinal research, cartilage physiology and diseases involving the degeneration of cartilage tissue. More specifically, the invention relates to methods and means for identifying compounds that inhibit catabolic processes in chondrocytes and that decrease the degradation of cartilage and/or ECM. The invention also relates to the compounds that are useful in the treatment of osteoarthritis. The invention also relates to targets, the modulation of which results in a decrease in the degradation of ECM and/or cartilage and decrease inflammation. In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by the degradation of ECM and/or cartilage and inflammation. |
| 申请公布号 |
US2016208266(A1) |
申请公布日期 |
2016.07.21 |
| 申请号 |
US201615014290 |
申请日期 |
2016.02.03 |
| 申请人 |
Brys Reginald Christophe Xavier;Nelles Luc;Vandeghinste Nick Ernest Rene;Mille-Baker Blandine;Tessari Michela Angela |
发明人 |
Brys Reginald Christophe Xavier;Nelles Luc;Vandeghinste Nick Ernest Rene;Mille-Baker Blandine;Tessari Michela Angela |
| 分类号 |
C12N15/113;G01N33/68;G01N33/50 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for identifying a compound that inhibits ECM and/or cartilage degradation, comprising:
(a) contacting a compound with a polypeptide comprising an amino acid sequence selected from the group consisting of SEQ ID NO: 39, 40, 27, 42, 22-26, 28-38, and 41 and fragments thereof; and (b) measuring a compound-polypeptide property related to ECM and/or cartilage degradation. |
| 地址 |
Mechelen BE |
