HUMAN MESOTHELIN CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
摘要
Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor (CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.
申请公布号
SG11201604815R(A)
申请公布日期
2016.07.28
申请号
SG11201604815R
申请日期
2014.12.19
申请人
NOVARTIS AG;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
发明人
BEATTY, GREGORY;ENGELS, BORIS;IDAMAKANTI, NEERAJA;JUNE, CARL H.;LOEW, ANDREAS;SONG, HUIJUAN;WU, QILONG