METHODS OF PREVENTION AND TREATMENT OF VIRAL DISEASE BY USE OF DDX3 INHIBITORS

摘要

In accordance with one or more embodiments, the present invention provides methods for treating a viral infection in a subject comprising administering to the subject a therapeutically effective amount of a fused benzodiazepine compound of Formulas I-V or a salt, solvate, stereoisomer of derivative thereof. In some embodiments, the viral infections are viruses from the family Flavivirdae, including Hepatitis C virus. Other embodiments include methods where the fused benzodiazepine compound of Formulas I-V are combined with other anti-viral agents. Methods for screening compounds for antiviral activity are also provided.