MODIFICATION OF BIOABSORBABLE STENT TO REDUCE THROMBOGENECITY

摘要

Bioabsorbable polymer scaffolds with coatings are disclosed that include immobilized antithrombotic agents on the scaffolds or in or on the coatings. The agents act synergistically with antiproliferative agents released from coatings by providing hemocompatibility during and without interfering with antiproliferative agent release. Methods of modifying scaffolds and coatings with the antithrombotic agents are disclosed.

主权项

1. A bioabsorbable stent comprising:
a poly(L-lactide) (PLLA) scaffolding composed of a plurality of struts having a thickness between 100 and 200 microns and; a first coating layer above all or a portion of the PLLA scaffolding having a thickness less than 5 microns, wherein the coating layer comprises an antiproliferative drug distributed throughout a coating polymer, wherein immobilized antithrombotic agent is at an outer surface of the coating layer, wherein the coating layer is free of the immobilized antithrombotic agent below the outer surface of the coating layer, wherein the antithrombotic agent is selected from the group consisting of heparin, non-adhesive proteins, cell adhesive proteins, cell adhesive peptide sequences, and hydrophilic monomers or polymers.