Mechanically robust fast-dissolving microneedles for transdermal drug and vaccine delivery

摘要

Disclosed are biocompatible, dissolving microneedle structures with enhanced mechanical strength. More particularly, the present disclosure relates to microneedles containing nanomaterials. Also disclosed are methods of producing such microneedle structures, as well as methods for using them to deliver drugs or biomolecules into the skin or epithelia, or the cytoplasm and/or nucleus of a skin or epithelia cell, of a subject.

主权项

1. A microneedle structure comprising a plurality of microneedles, wherein each of said microneedles is comprised of at least one dissolvable polymer and a nanomaterial, wherein said nanomaterial is well-dispersed throughout each of said microneedles, and wherein said nanomaterial comprises layered double hydroxide nanoparticles in a concentration between about 5 wt % and about 10 wt % relative to the mass of said polymer in the composite solution, and wherein said polymer comprises sodium carboxymethylcellulose.