Method for producing NO/N₂gaseous mixtures intended for the medical field

摘要

The invention relates to a method for producing an NO/N2 gaseous mixture, comprising the steps of effecting a purification of impure gaseous nitrogen containing impurities at least of the O2 type by putting the impure nitrogen in contact with a catalyst and then with a molecular sieve; mixing the pure nitrogen obtained with nitric oxide (NO), and obtaining a mixture formed from NO and pure nitrogen containing an NO content of less than 20% by volume and a proportion of impurities of the O2 type of less than 5 ppmv and of the H2O type of less than 40 ppmv. The NO/nitrogen mixture may undergo supplementary dilutions with pure nitrogen. Such NO/nitrogen mixtures can be used for treating, by inhalation, pulmonary vasoconstrictions in adults or children, in particular in new-born babies suffering from primitive pulmonary hypertension or in patients undergoing heart surgery.

主权项

1. A method for producing an NO/N2 gaseous mixture, comprising the steps of:
a) carrying out a purification of impure gaseous nitrogen containing O2 impurities by:
i) putting the impure nitrogen in contact with a nickel catalyst in order to convert at least some of the O2 impurities to H2O,ii) putting the nitrogen purified at substep i) in contact with a molecular sieve in order to eliminate at least some of the H2O resulting from step i), b) mixing the pure nitrogen resulting from step a) with nitric oxide (NO), c) obtaining a mixture formed from NO and pure nitrogen containing an NO content of less than 20% by volume and O2 at less than 5 ppmv and H2O at less than 40 ppmv.