ENANTIOSELECTIVE PRODUCTION OF CHIRAL CARBOXYLIC ACIDS

摘要

A process for enantioselectively converting an aldehyde, a bisulfite adduct of an aldehyde or a glycidate to a chiral carboxylic acid is disclosed. The process utilizes a microorganism or an enzyme preparation from a microorganism and is particularly useful for producing NSAIDs of the profen class from readily available precursors. Bacteria, yeasts and fungi are exemplified as capable of transforming precursors to profens.