发明名称 |
Process for the preparation of 3-¬(4-fluorophenyl) sulfonyl -2-hydroxy-2-methyl propionic acid |
摘要 |
The present invention relates to a process for the preparation of 3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropionic acid, which comprises the step of reacting 3-chloro-2-methyl-2-hydroxypropionic acid with a salt of 4-fluorophenylsulfinic acid, and the use of (+/-)- and (-)-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropionic acid and (+)-3-chloro-2-methyl-2-hydroxypropionic acid in the preparation of bicalutamide.
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申请公布号 |
EP1669347(A1) |
申请公布日期 |
2006.06.14 |
申请号 |
EP20040029364 |
申请日期 |
2004.12.10 |
申请人 |
HELM AG;CF PHARMA GYOGYSZERGYARTO KFT. |
发明人 |
BOR, ADAM;OROSZ, GYOERGY;LUKACS, FERENC;SCHNEIDER, GEZA |
分类号 |
C07C315/00;C07C59/115;C07C315/04;C07C317/46 |
主分类号 |
C07C315/00 |
代理机构 |
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主权项 |
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地址 |
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