SELECTIVE MODULATION OF TUMOUR NECROSIS FACTOR RECEPTORS IN THERAPY
摘要
This invention relates to the identification and characterisation of specific cellular responses which are associated with tumour necrosis factor receptor 1 (TNFRl) and tumour necrosis factor receptor 2 (TNFR2). Selective modulations of these responses may be useful in the promotion or inhibition of cell growth, for example, in the treatment of disease conditions, including cardiovascular and kidney diseases. Therapeutic methods employed selective TNFRl and TNFR2 modulators are provided, along with screening methods for the identification of selective TNFRl and TNFR2 modulators useful in such methods.
申请公布号
WO2006109044(A3)
申请公布日期
2006.12.21
申请号
WO2006GB01313
申请日期
2006.04.11
申请人
YALE UNIVERSITY;CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED;BRADLEY, JOHN;POBER, JORDAN;CLARK, PAUL;MIN, WANG;KLUGER, MARTIN
发明人
BRADLEY, JOHN;POBER, JORDAN;CLARK, PAUL;MIN, WANG;KLUGER, MARTIN