QUENCH LIQUIDS AND WASHING SYSTEMS FOR PRODUCTION OF MICROPARTICLES

摘要

The present invention provides coacervation methods forming compositions for the sustained release water soluble active agents, including biologically active polypeptides. The invention further relates to the discovery of improved non¬ aqueous quench liquids and washing systems, which enable a reduction in the amount and concentration of hardening agents such as heptane used to produce microparticles, while providing acceptable product yields and residual solvent levels.