MICROARRAYS FOR DETECTION AND IDENTIFICATION OF MICROORGANISMS ASSOCIATED WITH PERIODONTAL DISEASES AND METHOD FOR DIAGNOSIS OF INFECTIOUS ORAL DISEASES USING THE MICROARRAY

摘要

The present invention relates to a method for detection and identification of periodontal disease-causing infectious bacteria and a method for diagnosis of oral disease using the same. More particularly, the present invention relates to a microarry comprising at least one of gram positive bacteria-specific and gram negative bacteria- specific oligonucleotides, periodontal disease-causing bacteria's genus-specific and species-specific oligonucleotides designed from the ITS target region which is hypervariable, and all kinds of bactera's universal oligonucleotides designed from 23S rDNA which is conserved, a method for detection and identification of periodontal disease-causing bacteria, and a kit for diagnosis of infectious oral disease using the microarray. According to the present invention, the present invention can provide a speedy and perfect microarry method for detecting periodontal disease at the initial stage. Therefore, diverse systemic diseases including Cardiovascular System disease caused by bacteria associated with periodontal disease can be improved.