发明名称 |
METHODS AND MATERIALS FOR IDENTIFYING THE ORIGIN OF A CARCINOMA OF UNKNOWN PRIMARY ORIGIN |
摘要 |
The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into a linear discrimination analysis where the linear discrimination analysis normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the linear discrimination analysis or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers. |
申请公布号 |
EP2125034(A4) |
申请公布日期 |
2010.01.27 |
申请号 |
EP20080714156 |
申请日期 |
2008.02.01 |
申请人 |
VERIDEX, LLC |
发明人 |
WANG, YIXIN;MAZUMDER, ABHIJIT;TALANTOV, DMITRI;JATKOE, TIMOTHY;BADEN, JONATHAN F. |
分类号 |
A61K49/00;C07H21/04;C12Q1/68;G01N33/574 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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地址 |
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