BIOMARKERS AND USES THEREOF

摘要

The present invention provides markers of regulatory T (Treg) cells, preferably, cell surface markers of Treg cells and uses of those markers or compounds that bind thereto to identify or isolate Treg cells or to diagnose/prognose/treat/prevent Treg-mediated conditions. The present invention also provides methods for identification and/or isolation of Treg cell subpopulations and such isolated subpopulations of Treg cells.

主权项

1. A method for detecting a regulatory T (Treg) cell comprising determining the level of expression of a nucleic acid or protein set forth in Table 2 and/or Table 3, or a nucleic acid or protein having at least about 70% identity thereto, in/on a T cell, wherein an increased level of expression of a nucleic acid or protein set forth in Table 2 or a nucleic acid or protein having at least about 70% identity thereto compared to another cell type, or a reduced level of expression of a nucleic acid or protein set forth in Table 3 or a nucleic acid or protein having at least about 70% identity thereto compared to another cell type is indicative of a Treg cell.