METHODS OF SCALING DATA USED TO CONSTRUCT BIOSENSOR ALGORITHMS AS WELL AS DEVICES, APPARATUSES AND SYSTEMS INCORPORATING THE SAME

摘要

Methods are disclosed for scaling body fluid analysis data to correct and/or compensate for confounding variables such as hematocrit (Hct), temperature, variations in electrode conductivity or combinations thereof before providing an analyte concentration. The scaling methods utilize current response data obtained from an AC block applied prior to a DC block to minimize the impact of such confounding variables upon the observed DC current response before creating descriptors or algorithms. The scaling methods therefore compensate the measured DC current by using data from the AC block made on the same sample. Also disclosed are devices, apparatuses and systems incorporating the various scaling methods.

主权项

1. A method of scaling amperometric data obtained during an electrochemical analysis of an analyte of interest to compensate for hematocrit, the method comprising the steps of:
applying to a body fluid sample test sequence comprising at least AC block of low-amplitude signals in connection with at least one DC block, wherein the body fluid sample comprises the analyte of interest; measuring AC and DC current responses to an electro-active species indicative of the analyte of interest; determining a solution resistance (Rsolution) from AC current response information; and scaling the amperometric data by multiplying the DC current responses by Rsolution to obtain a compensated voltage drop that minimizes an influence of hematocrit on analyte concentration.