HETEROCYCLIDENE-N-(3,4-DIHYDRO-2(1H)-QUINAZOLIN-5-YL) ACETAMIDE DERIVATIVE

摘要

Disclosed are a compound for regulating transient receptor potential vanilloid type I receptor (TRPV1 receptor) function; a TRPV1 receptor antagonist; and an agent for prevention and/or treatment of diseases, including aches, associated with TRPV1 receptor. Disclosed are a compound represented by formula (I), a salt thereof, a solvate thereof, and a pharmaceutical composition containing any one of the compound, salt and solvate as an active ingredient. (In the formula, m represents 0 or 1; R1 represents a C1-C2 alkyl group; R2 and R3 independently represent H, OH or a C1-C4 alkyl group which may be substituted by a C1-C2 alkoxy group, or alternatively, R2 and R3 may form a cyclo ring together with a carbon atom to which R2 and R3 are bonded and the cyclo ring may form a non-aromatic heterocyclic group containing O; and Z represents a methylene group, an ethylene group or -NH-.)