发明名称 |
IMMUNOGENIC COMPOSITIONS AND VACCINES FOR PREVENTING OR TREATING FILARIAL DISEASE |
摘要 |
The present disclosure is directed to an immunogenic composition and method for preventing or treating a filarial disease including: at least one or at least two isolated polypeptides or immunogenic fragments thereof, and optionally a pharmaceutically acceptable carrier, wherein each polypeptide is expressed on a luminal surface of an intestine of a filarial worm, wherein each polypeptide is expressed at a level at least two-fold higher in the intestine in comparison to the level of expression of each polypeptide in a reproductive tract or a body wall of the filarial worm, wherein each isolated polypeptide has at least one transmembrane domain, and wherein each polypeptide is a non-mitochondrial polypeptide. |
申请公布号 |
WO2016149460(A1) |
申请公布日期 |
2016.09.22 |
申请号 |
WO2016US22787 |
申请日期 |
2016.03.17 |
申请人 |
THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC. |
发明人 |
MITRE, Edward, E.;MORRIS, Christopher;BENNURU, Sasisekhar;NUTMAN, Thomas |
分类号 |
A61P33/10;A61K38/16;A61K39/00;C07K14/00 |
主分类号 |
A61P33/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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