Biologically Cleavable Tetrapeptide Linking Agents

摘要

Tetrapeptide linkers for reversibly linking a first compound to a amine-containing second compound are described. Compounds containing the tetrapeptide linkers and methods of using the tetrapeptide linkers are also described.

主权项

1. A tetrapeptide linker comprising the structure represented by:wherein,
R4 is a side chain of a natural, non-natural isomeric, or synthetic hydrophobic L amino acid R3 is a side chain of a uncharged hydrophilic or basic hydrophilic L amino acid, and R2 is a side chain of a natural, non-natural isomeric, or synthetic hydrophobic L amino acid.