| 摘要 |
Provided herein are dihydropyrimidine compounds and their pharmaceutical applications, especially for use in treating and preventing HBV diseases. Specifically, provided herein are compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof, wherein the variables of the formulas are as defined in the specification. Also provided herein is the use of the compounds having Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, or a pharmaceutically acceptable salt thereof for treating and preventing HBV diseases.; |
| 主权项 |
1. A compound of Formula (I) or (Ia), or an enantiomer, a diastereoisomer, a tautomer, a hydrate, a solvate, a prodrug, a stereoisomer, an N-oxide, or a pharmaceutically acceptable salt thereof, wherein each R1 is independently H, F, Cl, Br, I, nitro, trifluoromethyl or cyano; each R2 is independently methyl or ethyl; each R3 is independently thiazolyl, oxazolyl or imidazolyl; wherein optionally each of thiazolyl, oxazolyl and imidazolyl is independently unsubstituted or substituted with methyl or cyclopropyl; each Z is independently O or S; each R4 is independently —(CR5R5a)tC(═O)—OH; each R4a is independently H, methyl or isopropyl; each R5 and R5a is independently H, F or methyl, or R5 and R5a, together with the carbon atom to which they are attached, form cyclopropyl or —C(═O); wherein each n is independently 1, 2 or 3; each m is independently 0, 1 or 2; and t is 1,2, 3 or 4. |
