ANTIBODIES THAT IMMUNOSPECIFICALLY BIND TO TRAIL RECEPTORS

摘要

The present invention relates to antibodies and related molecules that immunospecifically bind to TRAIL receptor, TR7. Such antibodies have uses, f or example, in the prevention and treatment of cancers and other proliferative disorders. The invention also relates to nucleic acid molecules encoding ant i- TR7 antibodies, vectors and host cells containing these nucleic acids, and methods for producing the same. The present invention relates to methods and compositions for preventing, detecting, diagnosing, treating or ameliorating a disease or disorder, especially cancer and other hyperproliferative disorder s, comprising administering to an animal, preferably a human, an effective amou nt of one or more antibodies or fragments or variants thereof, or related molecules, that immunospecifically bind to TRAIL receptor TR7.