| 摘要 |
PROBLEM TO BE SOLVED: To provide a composition capable of securing long term stability even if dextrin is not contained, the composition containing nanoparticles of low molecular-weight heparin and protamine.SOLUTION: The invention provides a production method of an agent containing nanoparticles containing LMWH and protamine (LMWH/P NPs), the method comprising adding a diluted protamine solution to a diluted LMWH solution with a physiological salt solution and stirring it.SELECTED DRAWING: Figure 1 |
