2'-Branched Nucleosides for Treatment of Viral Infections

摘要

The present invention provides a compound of formula I:;;or a pharmaceutically acceptable salt thereof, wherein R1 is defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, West Nile virus, Japanese encephalitis virus, tick-borne encephalitis virus, Kunjin virus, Murray Valley encephalitis, St Louis encephalitis, Omsk hemorrhagic fever virus, bovine viral diarrhea virus, Zika virus and Hepatitis C virus.

主权项

1. A compound of formula I, or a pharmaceutically acceptable salt thereof: wherein R1 is R2 is a C1-C6 alkyl optionally substituted with halogen, a C3-C7 cycloalkyl optionally substituted with halogen, a phenyl optionally substituted with halogen or C1-C4alkyl or a C1-C4alkyl-phenyl optionally substituted with halogen or C1-C4alkyl; R3 is H or C1-C4 alkyl R2 and R3 taken together and the carbon atom they are attached form a C3-C7 cycloalkyl; R4 is C1-C8 alkyl optionally substituted with halogen or C1-C4alkoxy, a C3-C7 cycloalkyl optionally substituted with halogen, a phenyl optionally substituted with halogen or C1-C4alkyl; a C1-C4alkyl-phenyl optionally substituted with halogen or C1-C4alkyl or a 4 to 7 membered heterocycle containing 1 to 3 heteroatom selected from N, S, and O, wherein said heterocycle is optionally substituted with one or more halogen, or C1-C4 alkyl.