GRISEOFULVIN DERIVATIVES

摘要

The present invention relates to compounds of the following general formula (I), or to a pharmaceutically acceptable salt thereof, as well as to the uses thereof as a drug, in particular for treating cancerous or precancerous hyperproliferative conditions, and to the pharmaceutical compositions containing same.;

主权项

1. A compound of following formula (I):or a pharmaceutically acceptable salt thereof,where:
represents a single or double bond; Y is C═O, C═S, CH2, CH—OR1, CHN3, CHNR2R3, C═N—OR4, C═N—NR5R6, Z is a hydrogen atom or a R9 group, and X is a CH—R10 group when represents a single bond or a C—R10 group when represents a double bond,with:
R1 to R5 each independently representing a hydrogen atom or a (C1-C6)alkyl, aryl, (C1-C6)alkyl-aryl, aryl-(C1-C6)alkyl or 5- or 6-membered heterocycle group; R6 representing a hydrogen atom or a (C1-C6)alkyl, aryl, (C1-C6)alkyl-aryl, aryl-(C1-C6)alkyl, C(O)NH2, C(S)NH2 or 5- or 6-membered heterocycle group; R9 representing —R14, —NHR14, —CH2—NHR14, —CH2—NH—C(O)—R14, —NH—CH2—R14, —NH—NH—R14, —NH—C(O)—R14, —NH—C(O)—CH2—R14, —NH—CH2—C(O)—R14, —NH—CH2—C(O)—O—R14, —NH—CH2—C(O)—NH—R14, —NH—SO2—R14, —S(O)—R14, —SO2—R14, —S(O)—CH2—R14, —SO2—CH2—R14 or —NR16R17; R10 representing a —S(O)R15 or —S(O)2R15 group; R14 representing a (C1-C6)alkyl, carbocycle, heterocycle, biaryl, carbocycle-(C1-C6)alkyl or heterocycle-(C1-C6)alkyl group, optionally substituted; R15 representing optionally substituted (C1-C6)alkyl, optionally substituted aryl, (C1-C6)alkyl-aryl, aryl-(C1-C6)alkyl, carbocycle, optionally substituted heterocycle, biaryl, carbocycle-(C1-C6)alkyl or heterocycle-(C1-C6)alkyl, and R16 and R17 together forming, with their carrier nitrogen atom, a heterocycle optionally substituted with —R14, —OR14 or —NHR14.