HYBRID COMPOUNDS OF CURCUMIN AND MELATONIN AS NEUROPROTECTANTS FOR NEURODEGENERATIVE DISORDERS

摘要

Hybrid compounds of curcumin and melatonin as neuroprotectants are provided. The hybrid compounds are useful for the treatment and/or prevention of Alzheimer's disease (AD), as well as other neurodegenerative diseases. The hybrid compounds exhibited superior and potent neuroprotection in an AD model.

主权项

1. A compound having the general formula:wherein
R is a substituted or unsubstituted aromatic or heteroaromatic group; R2 is selected from the group consisting of H, OH, NH2, NO2, and C1-C8 alkoxyl; R3 is selected from the group consisting of H and C1-C4 alkyl; X is S or O or NH or substituted-N, wherein the substituent is selected from the group consisting of C1-C8 alkyl, isopropyl, tert-butyl, saturated or unsaturated monocyclic ring with ring size ranging from 3-7, and unsubstituted or substituted phenyl ring which is optionally substituted with one or more substituents selected from the group consisting of C1-C8 alkyl, C1-C8 alkoxyl, C1-C8 alkylcarbonyl, halogen, hydroxyl, amino, nitro, and cyano; and Y is selected from the group consisting of C1-C4 alkyl.