| 发明名称 |
METHODS FOR USING EXTRACELLULAR ADENOSINE INHIBITORS AND ADENOSINE RECEPTOR INHIBITORS TO ENHANCE IMMUNE RESPONSE AND INFLAMMATION |
| 摘要 |
A method is provided herein to increase an immune response to an antigen. The method includes administering an agent that inhibits extracellular adenosine or inhibits adenosine receptors. Also disclosed are methods to increase the efficacy of a vaccine and to increase an immune response to a tumor antigen or immune cell-mediated tumor destruction. |
| 申请公布号 |
US2016346386(A1) |
申请公布日期 |
2016.12.01 |
| 申请号 |
US201615237316 |
申请日期 |
2016.08.15 |
| 申请人 |
The Government of the United States of America as represented by the Secretary of the Department of |
发明人 |
Sitkovsky Michail V.;Ohta Akio |
| 分类号 |
A61K39/39;A61K45/06;A61K31/53;G01N33/50;A61K31/519;A61K31/7088;A61K39/00;A61K35/17;A61K31/522 |
主分类号 |
A61K39/39 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for screening for an adenosine A2a receptor antagonist, comprising:
contacting an immune cell with an agent; and assaying for increased activity of the immune cell as compared to a control in the absence of the agent, wherein increase activity of the immune cell indicates that the agent is an adenosine A2a receptor antagonist. |
| 地址 |
Bethesda MD US |
