NEW INDOLE DERIVATIVES AS FACTOR XA INHIBITORS

摘要

THE PRESENT INVENTION RELATES TO COMPOUNDS OF THE FORMULA 1IN WHICH R0;R1;R2;R3;R4;R5;R6;R7;Q;V,G AND M HAVE THE MEANINGS INDICATED IN THE CLAIMS. THE COMPOUNDS OF THE FORMULA 1 ARE VALUABLE PHARMACOLOGICALLY ACTIVE COMPOUNDS. THEY EXHIBIT A STRONG ANTITHROMBOTIC EFFECT AND ARE SUITABLE, FOR EXAMPLE, FOR THE THERAPY AND PROPHYLAXIS OF CARDIOVASCULAR DISORDERS LIKE THROMBOEMBOLIC DISEASES OR RESTENOSES. THEY ARE REVERSIBLE INHIBITORS OF THE BLOOD CLOTTING ENZYMES FACTOR XA(FXA) AND/OR FACTOR V11A (FV11A), AND CAN IN GENERAL BE APPLIED IN CONDITIONS IN WHICH AN UNDESIRED ACTIVITY OF FACTOR XA AND/OR FACTOR V11A IS PRESENT OR FOR THE CURE OR PREVENTION OF WHICH AN INHIBITION OF FACTOR XA AND/OR FACTOR V11A IS INTENDED.THE INVENTION FUTHERMORE RELATES TO PROCESSES FOR THE PREPARATION OF COMPOUNDS OF THE FORMULA 1, THEIR USE, IN PARTICULAR AS ACTIVE INGREDIENTS IN PHARMACEUTICALS, AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM.