TETRAHYDROPROTOBERBERINE COMPOUNDS, THEIR MANUFACTURE, MEDICINAL COMPOSITION AND USES.

摘要

The present invention affords tetrahydroprotoberberine compounds listed as formula (I) and their pharmaceutically acceptable inorganic or organic salts, crystallized hydrates, solvates and medicinal compositions. In the formula (I), R<SUB>1</SUB>, R<SUB>2</SUB>, R<SUB>3</SUB> and R<SUB>4</SUB> represent H, lined or branched chain C<SUB>1-4 </SUB>alkyl, cyclopropyl, cyclopropyl methyl, methoxyl methyl, methoxycarbonylmethyl, aryl, benzyl, allyl, or substituted aryl or benzyl. R<SUB>5</SUB> and R<SUB>6</SUB> represent H, halogen, OH, SH, NO<SUB>2</SUB>, NH<SUB>2</SUB>, substituted or non-substituted lined or branched C<SUB>1-4</SUB> alkyl. The configuration of C-14 is R, S or its racemate. The present invention also provides their preparation process and application in preparing medicine for treating neurological diseases, especially dopamine receptor related neurological diseases.