发明名称 |
E. coli mediated siRNA silencing of Avian influenza in chickens |
摘要 |
Products and associated methods are described for the delivery of one or more small interfering RNAs (siRNAs) to an avian cell using a nonpathogenic bacterium for the prevention or treatment of Avian Influenza Virus (AIV). The siRNA is complementary to an mRNA of the AIV NP or PA sequence. In challenge studies with chickens, the siRNA is shown to prevent the onset of clinical symptoms or reduce the severity of disease, including reducing viral titers or virus shedding. |
申请公布号 |
AU2015209208(A1) |
申请公布日期 |
2016.08.11 |
申请号 |
AU20150209208 |
申请日期 |
2015.01.23 |
申请人 |
COLORADO STATE UNIVERSITY RESEARCH FOUNDATION |
发明人 |
LINKE, LYNDSEY M.;SALMAN, MO D.;WILUSZ, JEFFREY |
分类号 |
A01N63/00;A61K48/00;C12N15/11 |
主分类号 |
A01N63/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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