PHOTOTHERMAL SPECTROSCOPY SYSTEMS FOR OFFSET SYNCHRONOUS TESTING OF FLOW ASSAYS AND METHODS OF USING SAME

摘要

Embodiments disclosed herein are directed to photothermal spectroscopy apparatuses and systems for offset synchronous testing of flow assays. Methods of using and operating such photothermal spectroscopy systems are also disclosed.

主权项

1. A system for detecting a presence of an analyte in a sample disposed in a flow assay having optically-absorbing indicator particles therein, the system comprising:
a light source positioned and configured to irradiate at least a portion of the flow assay and the optically-absorbing indicator particles therein; a photothermal spectroscopy assay reader configured to capture a plurality of thermal signals of the flow assay including the optically-absorbing indicator particles; and a control system including control electrical circuitry operably coupled to the light source and the photothermal spectroscopy assay reader, the control electrical circuitry configured to synchronize operation of the light source and the photothermal spectroscopy assay reader at progressively offset time intervals and generate change in temperature per change in time data as a function of time data for a plurality of time data points at least partially based on a plurality of temperature readings each taken at one of the progressive offset time intervals.