Biphenylcarboxamide derivatives as hedgehog pathway modulators

摘要

C:/NRPonbUlCC/KXG/J3"2679_1 DOC.IM5/201 2 The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula 1. Ra R3 RG R7 Re 0 Y2 R9