METHOD FOR EXTRACTING FERULIC ACID AND/OR ITS SALTS

摘要

Method for extracting ferulic acid and/or its salts from a previously conditioned source rich in ferulic acid and its salts which comprises adsorbing the ferulic acid and/or its salts on a column packed with synthetic resin, desorbing the ferulic acid and/or its salts using an organic solvent, separating the liquor rich in ferulic acid into two fractions according to their water content, separately concentrating the two liquor fractions, mixing and concentrating said fractions, adding 2 volumes of water to them, concentrating the mixture obtained, separating out the insoluble impurities by sedimentation, pre-crystallizing the ferulic acid and/or its salts with a synthetic purification resin, crystallizing out the ferulic acid and/or its salts, separating the ferulic acid and/or its salts from the crystallization mother liquors and drying it and screening it.

主权项

1. A method for extracting ferulic acid and/or its salts from a previously conditioned source rich in ferulic acid and/or its salts free from suspended solids; the method comprises
i) adsorbing the ferulic acid and/or its salts in a column packed with a synthetic resin having affinity; ii) separating out the liquid fraction which is left with a reduced content of ferulic acid and/or its salts from the packed column containing the adsorbed ferulic acid; iii) desorbing the ferulic acid and/or its salts from the packed column with a counter-current flow of organic solvent in order to obtain a concentrated liquor of ferulic acid and/or its salts; iv) separating the concentrated liquor of ferulic acid and/or its salts into two fractions according to their water content; one fraction containing 50 to 70% of water, and the other only 5 to 10% of water; v) separately concentrating the two liquor fractions from 3.5 to 3.7 times their initial concentration; vi) pooling the two liquor fractions from the previous stage together; vii) concentrating the mixture from the previous stage from 2.5 to 3 times its initial volume by evaporation at 60-90° C.; viii) adding 2 volumes of water to the concentrated mixture from the previous stage; ix) concentrating the above mixture to approximately 1.7 times its initial concentration; x) separating out the insoluble impurities by sedimentation, allowing the above mixture to cool to around 20 to 40° C. and leaving it to stand for around 1 hour; xi) reheating the above mixture to 80° C.; xii) removing soluble impurities present in the above mixture by passing the mixture through a synthetic purification resin; xiii) crystallizing out the ferulic acid and/or its salts, removing the remaining solvent by evaporation from the mixture from the previous step, concentrating its volume by half, and transferring the resulting mixture into a crystallizing container with a cooling jacket, in which the ferulic acid and/or its salts precipitate out after standing for around 4 hours at 21° C., with a purity of 80 to 90% being obtained; xiv) separating out the crystals of free ferulic acid and/or its salts from the crystallization mother liquors by centrifuging; xv) drying the crystals of ferulic acid and/or its salts with drying equipment under vacuum and an inert atmosphere for around 2 hours until a moisture content of less than 1% is obtained; and xvi) screening the already dry ferulic acid and/or its salts.