发明名称 |
SPECIFIC PROTEASE INHIBITORS AND THEIR USE IN CANCER THERAPY |
摘要 |
<p>The present invention relates to a pharmaceutical composition comprising at least one inhibitor of EpCAM cleavage and at least one anti-EpCAM antibody, the use of least one inhibitor of EpCAM cleavage and at least one anti-EpCAM antibody for the manufacture of a medicament for the treatment and/or prevention of cancer, an in vitro method of inhibiting cancer by inhibiting cleavage of EpCAM, the use of a TACE inhibitor and/or a presenilin-2 inhibitor for inhibiting EpCAM cleavage, and a method of identifying a compound useful as an anti-cancer agent.</p> |
申请公布号 |
WO2007141029(A1) |
申请公布日期 |
2007.12.13 |
申请号 |
WO2007EP05077 |
申请日期 |
2007.06.08 |
申请人 |
GSF-FORSCHUNGSZENTRUM FUER UMWELT UND GESUNDHEIT GMBH;MAETZEL, DOROTHEA;MUENZ, MARKUS;GIRES, OLIVIER |
发明人 |
MAETZEL, DOROTHEA;MUENZ, MARKUS;GIRES, OLIVIER |
分类号 |
C07K16/30;A61K39/395;C07K14/705;C12N9/50 |
主分类号 |
C07K16/30 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|