| 摘要 |
PROBLEM TO BE SOLVED: To manufacture 3,3,3-trifluoro-2,2-dialkyl propionate ester useful as a manufacturing intermediate of a pharmaceutical compound simply with good yield.SOLUTION: 3,3,3-trifluoro-2,2-dialkyl propionate ester of the formula (II) is manufactured by reacting a monoester compound of the formula (I), where Rto Rrepresent each independently an alkyl group having 1 to 3 carbon atoms with SFin a presence of hydrofluoric acid anhydride (HF) of 1.5 to 100 times weight of the monoester compound.SELECTED DRAWING: None |
