| 发明名称 |
FGF MUTANTS AND USES THEREOF |
| 摘要 |
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions. |
| 申请公布号 |
US2016168223(A1) |
申请公布日期 |
2016.06.16 |
| 申请号 |
US201615004281 |
申请日期 |
2016.01.22 |
| 申请人 |
Amgen Inc. |
发明人 |
Belouski Edward John;Ellison Murielle Marie;Hamburger Agnes Eva;Hecht Randy Ira;Li Yue-Sheng;Michaels Mark Leo;Sun Jeonghoon;Xu Jing |
| 分类号 |
C07K14/50 |
主分类号 |
C07K14/50 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated polypeptide comprising an amino acid sequence of SEQ ID NO:4, further comprising the substitution of any amino acid for: the alanine residue at position 45, the leucine residue at position 86, the leucine residue at position 98, the alanine residue at position 111, the alanine residue at position 129, the glycine residue at position 170, the proline residue at position 171 or the serine residue at position 172, and combinations thereof. |
| 地址 |
Thousand Oaks CA US |
