ANTI-PODOCALYXIN ANTIBODIES AND METHODS OF USING THE SAME

摘要

The present invention is directed to compositions of matter useful for the treatment of cancer in mammals and to methods of using those compositions of matter for the same. Antibodies specific for podocalyxin designated Ab1 and 3G2 are disclosed, as is the use of said antibodies for the inhibition of growth of a tumor that expresses podocalyxin, and the use of said antibodies for targeting tumour endothelial cells that express podocalyxin.

主权项

1. An anti-podocalyxin antibody comprising at least one HVR sequence selected from the group:
(i) HVR-L1 comprising QASQSISNYLA (SEQ ID NO: 9) or QSISNY (SEQ ID NO: 17); (ii) HVR-L2 comprising RASTLAS (SEQ ID NO: 10) or RAS (SEQ ID NO:18); (iii) HVR-L3 comprising QQGYVSNNLDNIFGGGTEVVVK (SEQ ID NO: 11); (iv) HVR-H1 comprising SYAMG (SEQ ID NO: 6), GIDLSSYAMG (SEQ ID NO:12), or GIDLSSYA (SEQ ID NO: 13); (v) HVR-H2 comprising FIYASGSIFYASWAKG (SEQ ID NO: 7), FIYASGSI (SEQ ID NO: 14), or IYASGSI (SEQ ID NO: 15); and (vi) HVR-H3 comprising AGYYFGGNYDLNLWGQGTLVTVSS (SEQ ID NO: 8) or ARAGYYFGGNYDLNL (SEQ ID NO: 16).