ANTI-IL-12/IL-23 ANTIBODIES

摘要

Provided herein is an antibody comprising an antigen binding domain which binds to human IL-12 and human IL-23. The antibody binds human IL-12p40 existing as a monomer (human IL-12p40) and as a homodimer (human IL-12p80), and the antibody inhibits the binding of human IL-12 to human IL-12Rβ2 and human IL-23 to human IL-23R but does not inhibit the binding of human IL-12 or human IL-23 or human IL-12p40 or human IL-12p80 to human IL-12Rβ1.

主权项

1. An antibody which comprises three heavy chain CDR sequences selected from:(SEQ ID NO: 371)HCDR1 DYYX1H,wherein;X1 = M or L;(SEQ ID NO: 372)HCDR2 WIDPENGDTEX2APKFQG,wherein;X2 = Y, H, or S;(SEQ ID NO: 373)HCDR3 X3KELRYFDV,wherein;X3 = C, A, N, D, E, Q, G, H, I, L, P or V.and three light chain CDR sequences selected from:(SEQ ID NO: 374)LCDR1 RAX4X5SISINLH,wherein;X4 = S or P;X5 = Q or R;(SEQ ID NO: 375)LCDR2 FAX6QSX7S,wherein;X6 = S or R;X7 = I or T;(SEQ ID NO: 376)LCDR3 QQSNSX8PLT,wherein;X8 = W or F.