NEW PROCESS FOR PREPARING PI3K INHIBITOR BUPARSILIB

摘要

The present disclosure provides a new process for preparing PI3K inhibitor buparsilib. The whole reaction route of the present invention is simple and easy to control for the industrial production.

主权项

1. A method for preparing buparlisib of formula 1, comprising:
(1) contacting a compound of formula 2 with a compound of formula 3 to obtain a compound of formula 4; (2) contacting a compound of formula 6 with a compound of formula 5 and the compound of formula 4 to obtain the buparlisib of formula 1,