| 发明名称 |
TARGETING OF INNATE IMMUNE RESPONSE TO TUMOR SITE |
| 摘要 |
The invention provides microparticles or nanoparticles for treatment of tumors comprising: (i) a targeting agent to the tumor or the tumor environment; and (ii) at least one inducer that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. The targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment and are preferably antibodies. |
| 申请公布号 |
US2016317675(A1) |
申请公布日期 |
2016.11.03 |
| 申请号 |
US201615146045 |
申请日期 |
2016.05.04 |
| 申请人 |
GAVISH-GALILEE BIO APPLICATIONS LTD. ;HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT |
发明人 |
PITCOVSKI Jacob;SHAHAR Ehud;GORODETSKY Raphael |
| 分类号 |
A61K47/48;A61K9/48;C07K16/32;A61K9/50 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. Microparticles or nanoparticles for treatment of tumors comprising:
(i) a targeting agent to the tumor or the tumor environment, optionally biotinylated, wherein said targeting agent is an agent that recognizes and binds to an antigen, a receptor or other molecules found on the surface of tumor cells or in the tumor environment; and (ii) a sole or two or more inducers, optionally biotinylated that stimulates a desired immune response in the tumor environment, leading to tumor apoptosis, wherein components (i) and (ii) are non-covalently or covalently attached to the surface of said microparticles or nanoparticles. |
| 地址 |
KIRYAT SHMONA IL |
