| 摘要 |
Methods for treating a patient suffering from neural cell injury, the method comprising administering to the patient an effective amount of a HIF prolyl-4-hydroxylase inhibiting compound having the following general formula (1) wherein R1 is a cyclic group containing at least three and up to seven carbon atoms and optionally containing one or more heteroatoms selected from O, N, and S, and optionally attached to the shown carbon atom by a linking group; R2 is independently selected from said cyclic groups of R1 and acyclic hydrocarbon groups R5 containing up to twenty carbon atoms; R3 is selected from hydrogen atom and hydrocarbon groups containing up to six carbon atoms; R6 and R7 are independently selected from hydrogen atom, hydrocarbon groups containing up to three carbon atoms, halogen atom, and polar groups, as well as methylene-linked versions thereof; and t is 0 or 1. |
| 主权项 |
1. A method for treating a patient suffering from neural cell injury, the method comprising administering to said patient an effective amount of a HIF prolyl-4-hydroxylase inhibiting compound having the following general formula: wherein: R1 is a cyclic group containing at least three and up to seven ring carbon atoms and optionally containing one or more ring heteroatoms selected from O, N, and S, wherein said cyclic group is optionally substituted with one or more groups selected from —R4, —C(O)R4, —NR42, —OR4, NO2, —C(O)NR42, —NR4C(O)R4, —C(O)OR4, —OC(O)R4, —OC(O)NR42, —NR4C(O)NR42, —NR4C(O)OR4, —SO2R4, nitrile, and halogen atom, wherein R4 is, independently, hydrogen atom or acyclic hydrocarbon group containing up to six carbon atoms, and wherein said cyclic group is optionally attached to the shown carbon atom by a linking group; R2 is independently selected from said cyclic groups of R1 and acyclic hydrocarbon groups R5 containing up to twelve carbon atoms, wherein said cyclic group is optionally attached to the shown carbon or nitrogen atom by a linking group; R3 is selected from hydrogen atom and hydrocarbon groups containing up to six carbon atoms; R2 and R3 are optionally interconnected; R6 and R7 are independently selected from hydrogen atom, hydrocarbon groups containing up to three carbon atoms, halogen atom, and polar groups selected from —C(O)R4, —NR42, —OR4, —NO2, —C(O)NR42, —NR4C(O)R4, —C(O)OR4, —OC(O)R4, —OC(O)NR42, —NR4C(O)NR42, —NR4C(O)OR4, —SO2R4, and nitrile, as well as methylene-linked versions thereof; and t is 0 or 1. |
