RETINOID DOUBLE CONJUGATE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS FOR TREATING OF SKIN CONDITIONS

摘要

A double conjugate molecule made of a retinoid, an organic acid, particularly an α-hydroxy acid, and an alcohol or acyl group, is provided which is useful in treating skin conditions, particularly aging. The retinoid, organic acid, and alcohol/acyl group are preferably linked via ester bonds.

主权项

1: A molecule of formula (I):wherein
X is independently (CO)O, O(OC), S(O)2O, O(O)2S, (CS)O, O(SC), O—(CH2)a, (CH2)a—O, S(CH2)a, (CH2)a—S, (CO)N, N(CO), N(O)2S, or S(O)2N, a is 0 or 1, k is 1 or 2, A is a unit of formula (II):and
B is a unit of formula (III):
R6R7R8C—  (III),wherein
m and n are independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, R, R1, R2, R3, R4, and R5 are independently H, COOH, CHO, alkyl comprising 1 to 20 carbon atoms optionally substituted or interrupted by one or more OH, N, O, S, P, or F, (alk)aryl comprising 1 to 20 carbon atoms, optionally substituted or interrupted by one or more OH, N, O, S, P, or F, or one or more pairs of R1 and R2 or R4, and R5 forms a carbonyl, R6, R7, and R8 are independently H, alkyl comprising 1 to 20 carbon atoms optionally substituted by OH, CHO, COOR9, CR9OR9, CONR9R9, or (alk)aryl comprising 1 to 20 carbon atoms optionally substituted by OH, CHO, COOR9, CR9OR9, CONR9R9, and R9 is independently H or alkyl comprising 1 to 6 carbon atoms.