| 发明名称 |
LONG-ACTING POLYPEPTIDES AND METHODS OF PRODUCING AND ADMINISTERING SAME |
| 摘要 |
CTP-modified human growth hormone polypeptides and pharmaceutical formulations and pharmaceutical compositions comprising the same and methods of producing, and using the same are disclosed. |
| 申请公布号 |
US2016310576(A1) |
申请公布日期 |
2016.10.27 |
| 申请号 |
US201615200813 |
申请日期 |
2016.07.01 |
| 申请人 |
OPKO Biologics Ltd. |
发明人 |
FARES Fuad;Fima Udi Eyal |
| 分类号 |
A61K38/27;G01N33/74;A61K47/02;A61K38/24;A61K47/12 |
主分类号 |
A61K38/27 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A pharmaceutical formulation comprising a buffer, a tonicity agent, and a polypeptide consisting of a chorionic gonadotropin carboxy terminal peptide (CTP) modified growth hormone, wherein one chorionic gonadotropin carboxy terminal peptide (CTP) is attached to the amino terminus of said growth hormone, and two chorionic gonadotropin CTPs are attached to the carboxy terminus of said growth hormone, wherein said polypeptide optionally consists of a signal peptide attached to the amino terminus of said one CTP. |
| 地址 |
Nes Ziona IL |
