BIOMARKERS FOR DETECTION AND DIAGNOSIS OF HEAD AND NECK SQUAMOUS CELL CARCINOMA

摘要

Novel, sensitive and specific markers and methods for diagnostics and monitoring of head and neck squamous cell carcinoma (HNSCC) are provided. Kits and methods for the use of hyaluronic acid, hyaluronidase and CD44 to diagnose HNSCC are described.

主权项

1. A method of diagnosing head and neck squamous cell carcinoma (HNSCC), or elevated risk of future occurrence thereof, in a subject, the method comprising: assaying a subject sample for the presence of at least one biomarker selected from the group consisting of hyaluronic acid (HA); hyaluronidase (HAase), and total protein; wherein the detection of said biomarker(s) is correlated with a diagnosis of HNSCC, or an elevated risk of future occurrence thereof, the correlation taking into account the presence and level of biomarker(s) in the subject sample as compared to normal subjects.