| 发明名称 |
BIOCATALYSTS FOR EZETIMIBE SYNTHESIS |
| 摘要 |
The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides. |
| 申请公布号 |
US2016281068(A1) |
申请公布日期 |
2016.09.29 |
| 申请号 |
US201615179503 |
申请日期 |
2016.06.10 |
| 申请人 |
Codexis Inc. |
发明人 |
Crowe Michael A.;Alvizo Oscar;Behrouzian Behnaz;Bong Yong Koy;Collier Steven J.;Gohel Anupam;Mavinahalli Jagadeesh;Modukuru Naga K.;Mundorff Emily;Smith Derek J.;Song Shiwei;Yeo Wan Lin |
| 分类号 |
C12N9/04;C12P17/10 |
主分类号 |
C12N9/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polynucleotide encoding a non-naturally occurring ketoreductase polypeptide comprising an amino acid sequence that has at least 80% sequence identity to SEQ ID NO:2 and at least the following features: residue at position X40 is R; residue at position X153 is I, or L; residue at position X190 is A, or P; residue at position X196 is A, C, N, S, or T; residue at position X199 is F, or W; and residue at position X206 is I. |
| 地址 |
Redwood City CA US |
