| 摘要 |
PROBLEM TO BE SOLVED: To provide humanized and conjugated antibodies against CD79b useful for the treatment and/or detection of hematopoietic tumor in mammals and to provide methods of using those antibodies for the same.SOLUTION: An anti-CD79b antibody comprises: at least one HVR sequence selected from the group consisting of HVR-Ll comprising sequence A1-A15, HVR-L2 comprising sequence B1-B7, HVR-L3 comprising sequence C1-C9, HVR-Hl comprising sequence Dl-D10, HVR-H2 comprising sequence E1-E18, and HVR-H3 comprising sequence Fl-F10; and at least one variant HVR, in which the variant HVR comprises modification of at least one residue of specific sequences. |
