发明名称 |
COMPOSITIONS AND METHODS FOR ENHANCING PARACELLULAR PERMEABILITY ACROSS EPITHELIAL AND ENDOTHELIAL BARRIERS |
摘要 |
<p>Compositions and methods for enhancing paracellular permeability at an absorption site in a subject are disclosed. The method includes: (a) administering an effective amount of a phospholipase C inhibitor to a subject at a time in which enhanced paracellular permeability is desired; and (b) enhancing paracellular permeability in the subject at the absorption site through the administering of the effective amount of the phospholipase C inhibitor. The disclosed compositions and methods provide enhanced absorption of a hydrophilic drug in a subject.</p> |
申请公布号 |
EP1379235(B1) |
申请公布日期 |
2006.12.20 |
申请号 |
EP20010986603 |
申请日期 |
2001.10.10 |
申请人 |
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
THAKKER, DHIREN, R.;WARD, PETER, D. |
分类号 |
A61K31/685;A61K45/00;A61K31/353;A61K31/37;A61K31/56;A61K31/58;A61K31/661;A61K45/06;A61K47/24;A61P1/14;A61P25/00;A61P43/00 |
主分类号 |
A61K31/685 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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