Ion Mobility Method and Apparatus

摘要

A method and system for performing an ion mobility based analysis that ionizes the components of a sample into ions; provides a field asymmetric waveform ion mobility or differential mobility spectrometry ion mobility based filter that comprises at least two electrodes, the at least two electrodes being spaced apart such that a constant sized gap is formed there between, through which a drift gas flows; introducing said ions into the drift gas, wherein said drift gas also comprises a mixture of liquid modifiers.

主权项

1. A method of performing an ion mobility based analysis comprising
ionizing the components of a sample into ions; providing a field asymmetric waveform ion mobility or differential mobility spectrometry ion mobility based filter that comprises at least two electrodes, the at least two electrodes being spaced apart such that a constant sized gap is formed there between, through which a drift gas flows; introducing said ions into the drift gas, wherein said drift gas also comprises a mixture of liquid modifiers, said mixture comprising: a first solvent to improve the separation capability of said drift gas; a second solvent to suppress either proton transfer or analyte dissociation of said ions, said second solvent having a higher proton solvation energy than that of the first solvent, and being added in excess to that of said first solvent; and detecting the ions after they have passed through the drift gas.