METHODS OF INHIBITION OF PROTEIN FUCOSYLATION IN VIVO USING FUCOSE ANALOGS

摘要

PROBLEM TO BE SOLVED: To provide compositions for the inhibition of fucosylation of proteins, including antibodies, in vivo.SOLUTION: The present invention provides a pharmaceutical composition for use in the cancer treatment of mammals, comprising one fucose analog represented by formula (III) or (IV) or salt thereof [each of formulas (III) and (IV) is α or β anomer or the corresponding aldose form; R1, R3 and R4 each independently represent -OH or -OC(O)C1-C10 alkyl; R2 is F; R2a and R3a are H; R5 is-CH3].SELECTED DRAWING: Figure 8A