SERUM BIOMARKER FOR HEPATOCELLULAR CARCINOMA (HCC)
摘要
The present invention pertains to novel diagnostic procedures for the prognosis, diagnosis and monitoring of liver diseases such as hepatocellular carcinoma (HCC). The present invention provides sphingolipids and especially long chain ceramides as significant and highly prognostic serum biomarkers in HCC compared to liver cirrhosis. Therefore the invention in particular provides a method for detecting the presence or absence of a HCC in a liver cirrhosis patient using the disclosed biomarkers. Also provided is a method for monitoring the treatment success of a HCC treatment by monitoring the disclosed serum biomarkers. Finally the invention pertains to diagnostic kits for performing the disclosed methods of the invention.
申请公布号
EP3081938(A1)
申请公布日期
2016.10.19
申请号
EP20150164834
申请日期
2015.04.23
申请人
JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT AM MAIN