| 摘要 |
<p>This invention is in the field of chemical restructuring of pharmaceutica l agents known to cause tissue toxicity as a side effect, by producing their orotate derivatives. More particularly, it concerns orotate derivatives of the anthracyclines, doxorubicin and daunorubicin, that are found to reduce l evels of the pharmaceutical agent in noncancerous tissues. There orotate der ivatives are equally efficacious in inhibiting the SCCAKI-I kidney tumor in animals and the reduction in the heart tissue of doxorubicin compared with d oxorubicin HC1 suggests a reduction in toxicity induced by free radical gene ration by the anthracyclines.</p> |
