A LARGE SCALE METHOD FOR THE DEOXOFLUORINATION OF KETONES

摘要

A method for the deoxofluorination of a ketone for the production of a geminal difluoride compound in an industrial scale comprising the following steps: - preparing an educt mixture comprising a ketone and a dialkylaminosulfur trifluoride, - letting flow the educt mixture into a reaction chamber of defined length, diameter and volume, with a flow path having a width perpendicular to the direction of the flow in the range of 1-10 mm, at a temperature of at least 75 °C up to 120 °C, preferably between 80 and 100 °C, to perform the deoxofluorination reaction, said reaction chamber being continuously fed with the educt mixture, and obtaining a product mixture - quenching the product mixture with a basic aqueous solution in a cooled reservoir vessel.